Trimethoprim and Sulfamethoxazole TMP-SMX

Brand Name/ Company Septra /Glaxo Wellcome Inc. Bactrim /Roche Laboratories [Pg.43]

Class Synthetic antibacterial combinations with activity against Escherichia coii, Pro/eos species. Morganeiia morganii, Proteus mirahiiis, Kiebsielia species. Enterobacterspecies, Hemophiius influenzae, Streptococcus pneumoniae, Shigella flexneri, and Shigella sonnei 15 o u E c [Pg.43]

Mechanism of Action TMP-SMX blocks 2 consecutive steps in the biosynthesis of nucleic acids and proteins essential to many bacteria [Pg.43]

Indications IV Infusion Prophylaxis and treatment of Pneumocystis car/n/ pneumonia Shigellosis Severe or complicated urinary tract infections Tablets Prophylaxis and treatment of Pneumocystis carinii pneumonia Acute exacerbation of chronic bronchitis Urinary tract infections Travelers diarrhea in adults Shigellosis Acute otitis media [Pg.43]

Contraindications Hypersensitivity to TMP or SMX Megaloblastic anemia due to folate deficiency Pregnancy at term and nursing Infants 2 months of age [Pg.43]

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