Triiodothyronine biochemistry

B. Dozin, M.A. Magnuson, and V.M. Nikodem, Tissue-specific regulation of two functional malic enzyme mRNAs by triiodothyronine. Biochemistry Sept 24 5581 (1985). 

Several studies have failed to confirm the benefits of combined levothyroxine and liothyroninc therapy. Liothyroninc given once a day results in non-physiologi-cal peak serum concentrations of T3. Modified-release triiodothyronine plus thyroxine can normalize serum biochemistry, but it is not known whether this formulation is superior to levothyroxine alone (15). 

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