Trihydroxybufosterocholenic acid

In 1934, Shimizu and Oda isolated a major bile acid from the toad, Bufo vulgaris formosus, which they named trihydroxybufosterocholenic acid [48]. The structure of this bile acid was elucidated in 1967 by Hoshita et al. as 3a,7a,12a-trihydroxy-... 

Trihydroxybufosterocholenic acid (XII) (Fig. 7) (3a,7a, 12a-trihydroxy-24-methyl-j22-coprostanic acid) is an example of a 28-carbon-atom bile acid first isolated from the bile of the toad, Bufo vulgaris, by Shimizu and Oda (51). All known C27 and Cga bile acids occur in nature as conjugates with the amino acid, taurine. There are several other acids in this group, which will be described in detail in subsequent chapters. 

This is the only Cjg steroid to be included as a bile acid or alcohol. It was isolated from toad bile by Shimizu and Oda (190) and named trihydroxy-bufosterocholenic acid. An isomeric acid has also been isolated (191). Tri-hydroxybufosterocholenic acid has been degraded by ozonization to bisnor-cholic acid (192). The saturated derivative of this acid, 3a,7a,12a-trihydroxy-coprostane-24-carboxylic acid, was characterized by partial synthesis (193). As a C28 acid, trihydroxybufosterocholenic acid presents a metabolic question. Cholesterol is not a precursor (194) though the livers of the animals from which the acid is isolated appear to contain mainly cholesterol (195). Hoshita et al. (193) proposed that the acid may arise from campesterol or from an intermediate formed during methylation at C-24. 

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See also in sourсe #XX -- [ ]

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