Triglycerides feeding studies

Triglycerides All subjects had normal triglyceride levels before, during, and after the feeding studies. And there was no change during... 

Quite an array of studies suggested that one function of Apo A-IV is in the formation and secretion of chylomicrons (for review see [17]). Recent data show that the production of Apo A-IV mRNA in rat enterocytes is stimulated by acute triglyceride feeding [1,16,25]. Studies in humans also argue for a stimulation of intestinal Apo A-rV synthesis by triglyceride feeding [4, 18, 32]. Intestinal Apo A-IV production obviously contributes to the postprandial elevation of plasma Apo A-I VIevels seen in... 

In the studies discussed, wheat bran, cellulose, and psyllium fiber feeding resulted in increased fecal fat losses and in lowered blood serum cholesterol and triglyceride levels (14,15,32,41) as well as increased fecal losses of calcium. Possible involvement of dietary fat with high or low dietary fiber intake has not been extensively investigated. However, that calcium is involved in intestinal fat absorption is generally accepted (42-45). 

The source of n-3 PUFAs used in human feeding trials has been either flaxseed or linseed oil as a source of ALA, fish and fish oils as sources of EPA and DHA, purified esters of EPA and DHA, or DHA triglycerides from genetically engineered algae. There are only a few human studies in which flaxseed or fish was fed, whereas there are several dozen studies with fish oils only. Results from these studies are summarized in the following section. 

With this background, the present investigation was undertaken. The effect on plasma total and HDL cholesterol, and triglycerides of two kinds of pectin with different degrees of methoxylation, and of guar gum was studied in 3-6 months feeding experiments with rats. Wheat bran and oat bran were also studied for comparison. Pectin and wheat bran was fed both with and without dietary cholesterol. 

The change in the 22 1 content with time on diet for the three species is shown in Fig. 2. The concentration of 22 1 in the cardiac triglycerides is compared to the concentration of this acid in the dietary oil and expressed as a ratio. As evident from these results, the 22 1 concentration of the rat heart triglycerides is the same as that of the dietary oil during the first week on the experimental diet. The ratio of 22 1 then decreases on continued feeding to a ratio of approximately 0.5 after 16 weeks. In the pig, the ratio was 0.2 throughout the 1 year study. The monkey shows a tendency to accumulate 22 1 in the cardiac triglyceride fraction. Erucic acid (22 1 n-9)... 

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