3.3.3- trifluoropropanal

Trifluoro-2-nitrosopropene can be generated in situ from 1 -bromo-3,3,3-trifluoropropan-2-one 2-oxime. It is a highly reactive nitrosoalkene that readily undergoes cycloaddition with silyl enol ethers and other die-nophiles to give CF3- substituted 1,2-oxazines (92JOC339). 

Carbon tetrachloride, 0322 Carbon tetrafluoride, 0349 Carbon tetraiodide, 0525 f 1-Chlorobutane, 1637 f 2-Chlorobutane, 1638 f Chlorocyclopentane, 1923 f l-Chloro-l,l-dilluoroethane, 0731 Chlorodilluoromethane, 0369 f Chloroethane, 0848 Chloroform, 0372 f Chloromethane, 0432 f l-Chloro-3-methylbutane, 1986 f 2-Chloro-2-methylbutane, 1987 f Chloromethyl ethyl ether, 1246 f Chloromethyl methyl ether, 0850 f l-Chloro-2-methylpropane, 1639 f 2-Chloro-2-methylpropane, 1640 f 1-Chloropentane, 1988 f 1-Chloropropane, 1243 f 2-Chloropropane, 1244 f l-Chloro-3,3,3-trifluoropropane, 1127 1,2-Dibromoethane, 0785 Dibromomethane, 0395... 

Kamitori investigated the synthesis of 4,5-bistrifluoromethylpyridazines 299 from 1-aryl-3,3,3-trifluoropropane-1,2-dione 1-hydrazones 298 (Equation 75). Mechanistically, the reaction is considered to occur via a [4+2]-type... 

Trichloro-3,3,3-trifluoropropane (26) with potassium hydroxide gives 1-chloro-3,3,3-tri-fluoroprop-l-yne (27).60... 

Hexachlor6-3-fluoropropane (CHCI2CCI2CCI2F).30 In a 1-1. flask, a mixture of 1160 g. of 1,1,2,2,3,3,3-heptachloropropane and 740 g. of antimony trifluorodichloride is vigorously stirred so that the temperar ture does not exceed 50°. After the mixture has cooled to 30°, it is slowly heated to 130-140° and maintained at this temperature for five hours. It is then cooled, poured into water, washed with hydrochloric acid—to remove antimony salts—then with water, anchdried. The yield is 907 g. of reaction product containing approximately 60 g. of 1,1,2,2-tetrachloro-3,3,3-trifluoropropane (b.p. 130°), 315 g. of 1,1,2,2,3-penta-chloro-3,3-difluoropropane (b.p. 168°), and 435 g. of 1,1,2,2,3,3-hexa-chloro-3-fluoropropane (b.p. 210°). 

Dichloro-3.3,3-trifluoropropanal, an intermediate for the production of substituted pyridines, was prepared by ozonolysis of methyl 4,4-dichloro-5,5.5-trifluoro-2-methylpent-2-enoate with reductive workup. ... 

The reaction of 3-amino-l-phenyl- and 3-amino-l(thien-2-yl)-4,4,4-tri-fluorobut-2-en-l-ones with 1,2-diaminopropane and l,2-diamino-3,3,3-trifluoropropane under kinetic control conditions (room temperature, 20 h) forms a mixture of cis and trans isomers of imidazolines, one of which prevails (isomer ratio 9 1) (99IZV2135,... 

Trifluorolactic acid. This compound can be prepared from l,2-epoxy-3,3,3-trifluoropropane in a Cu-catalyzed oxidation. 

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