Trifluoromethyl group, relaxation

Introduction of a w-trifluoromethyl group into the phenyl group of phenobarbitone (XXXIV) is said to modify its properties such that skeletal muscle relaxation is produced, at doses much lower than those that result in motor impairment [181]. 

Methyl groups of the aromatic ring of vitamins E and K have been replaced by trifluoromethyl. Replacement of the three methyls of the side chain by one or several trifluoromethyls (Wittig-Uke approach from ad hoc trifluoromethyl ketones) as well as the difluorination at CA (synthesized from bromodifluoroacetate) in vitamin E (tocopherol) have also been realized (Eigure 4.28). " The relaxation times T2 of the various CF3 groups have been measured in suspensions of hposomic bilayers and compared to those obtained in solution. The goal of these studies was to determine the mobility and the molecular orientation of the vitamin in a lipidic bilayer. 

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