Trifluoromethyl chloride

SYNS ARCTON 3 F 13 FREON 13 GENETRON 13 HALOCARBON 13/UCON 13 MONOCHLOROTRIFLUOROMETHANE (DOT) R13 R13 pOT) TRIFLUOROCHLOROMETHANE pOT) TRIFLUOROMETHYL CHLORIDE TRIFLUORO-iMONOCHLOROCARBON... 

TRIFLUOROMETHYL CHLORIDE (75-72-9) Violent reaction with aluminum. Reacts with magnesium, zinc, and their alloys. Reacts, possibly violently, with barium, sodium, and potassium. Undergoes thermal decomposition when exposed to red-hot surfaces or fire, forming chlorine, hydrogen fluoride or chloride, phosgene, and carbonyl fluoride. 

Synonyms CFC 13 Freon 13 Monochlorotrifluoromethane R13 Trifluorochloromethane Trifluoromethyl chloride Trifluoromonochlorocarbon Empirical CCIF3 Formula CF3CI... 

Trifluoromethylbenzene. See Benzotrifluoride Trifluoromethyl chloride. See Chlorotrifluoromethane o-(Trifluoromethyl) chlorobenzene. See o-Chlorobenzotrifluoride p-(Trifluoromethyl) chlorobenzene. See p-Chlorobenzotrifluoride Trifluoromethyidichlorocarbanilide 3-(Trifluoromethyl)-4,4 -dichlorocarbanilide 3-Trifluoromethyl-4,4 -dichloro-N,N -diphenylurea. See Cloflucarban 5-((2-T rifi uoromethyl phenyl) azo)-6-am i no-4-hydroxy-2-naphthalenesulfonic acid, sodium salt. See/Void red 337 m-Trifluoromethylphenyl chloride. See m-Chlorobenzotrifluoride o-TrifI uoromethyl phenyl chloride. See o-Chlorobenzotrifluoride p-TrifI uoromethyl phenyl chloride. See p-Chlorobenzotrifluoride... 

The direct insertion of indium C-X bond of bromoallqrlphosphonates (584) in the presence of CuCl afforded phosphorylated allq lindium reagents (585). A practical application of (585) has been evaluated in the synthesis of arylallg l phosphonates (586) via a Pd-catalysed crosscoupling reaction (Scheme 170). A wide range of functional groups, including ester, ketone, aldehyde, nitrile, nitro, trifluoromethyl, chloride, methojq, hydroxy, and amino, have been tolerable in this reactions. ... 

Very strongly deactivating 0 II —CCI —C=N —SO3H -CF3 —NO2 (acyl chloride) (cyano) (sulfonic acid) (trifluoromethyl) (nitro) Meta directing... 

Alkylation. Ben2otrifluoride can also be alkylated, eg, chloromethyl methyl ether—chlorosulfonic acid forms 3-(trifluoromethyl)ben2yl chloride [705-29-3] (303,304), which can also be made from / -xylene by a chlorination—fluorination sequence (305). Exchange cyanation of this product in the presence of phase-transfer catalysts gives 3-(trifluoromethylphenyl)acetonitrile [2338-76-3] (304,305), a key intermediate to the herbicides flurtamone... 

Reactions Involving the Trifluoromethyl Group. Aluminum chloride effects chlorinolysis of ben2otrifluoride to give ben2otrichloride (307). High yields of volatile acid fluorides are formed from ben2otrifluoride and perfluorocarboxyUc acids (308). 

Purine, 8-trifluoromethyl-pX, 5, 524 (58JA3932, 58JA5744, 59JA2515) Purine, 6-trimethylammonium chloride H NMR, 5, 511 (78JOC2587)... 

DETERMINATION OF l-[2-OXO-2-(TRIFLUOROMETHYL-10-PHENOTHIAZINYL)-ETHYL]-4-HYDROXYIMINOMETHYL-PYRIDINIUM CHLORIDE BY DERIVATIVE UV-SPECTROPHOTOMETRY... 

Triethylbenzylammonium chloride and potassium fluoride containing 1% water can provide chlorine-fluorine exchange of activated halides in the absence of a solvent. This mixture also can displace the chlorine of a chlorodifluoromethyl group to form a trifluoromethyl group [62] (equation 36). 

Upon nitration of 4 trifluoromethylbenzotnchlonde or -benzoyl chloride, a 76 3% yield of a mixture of 4-trifluoromethyl-2 and 3-nitrobenzoic acids is obtained [20]... 

Codeposition of silver vapor with perfluoroalkyl iodides at -196 °C provides an alternative route to nonsolvated primary perfluoroalkylsilvers [272] Phosphine complexes of trifluaromethylsilver are formed from the reaction of trimethyl-phosphme, silver acetate, and bis(trifluoromethyl)cadmium glyme [755] The per-fluoroalkylsilver compounds react with halogens [270], carbon dioxide [274], allyl halides [270, 274], mineral acids and water [275], and nitrosyl chloride [276] to give the expected products Oxidation with dioxygen gives ketones [270] or acyl halides [270] Sulfur reacts via insertion of sulfur into the carbon-silver bond [270] (equation 188)... 

This formulation is supported by the proton resonance spectrum of the trifluoromethyl compound 101 which shows that it exists in the CH form shownd However, strong electron-withdrawing groups in the 4-position apparently lead to enolization, and compound 102, for example, gives an intense color with ferric chloride, - Other 4-acylated oxazol-5-ones are often formulated as 103 (see, e.g, reference 113). Tautomerism of the type illustrated by the equilibrium 104 103 has been discussed (see reference 115 for further references). 

B) Preparation of S-Trifluoromethyl-2,4-Disulfamylaniline—The 5-trifluoromethylaniline-2,4-disulfonyl chloride obtained in step (A) is taken up in ether and the ether solution dried with magnesium sulfate. The ether is removed from the solution by distillation, the residue is cooled to 0°C, and 60 ml of ice-cooled, concentrated ammonia water is added while stirring. The solution is then heated for one hour on a steam bath and evaporated... 

A solution of 1.0 gram of 10-[3 -(N-acetoxyethylpiperazinyl)-propyl]-2-trifluoromethyl-phenothiazine in 25 ml of 1 N hydrochloric acid is heated at reflux briefly. Neutralization with dilute sodium carbonate solution and extraction with benzene gives the oily base, 10-[3 -(N-(3-hydroxyethylpiperazinyl)-propyl]-2-trifluoromethylphenothiazine. The base is reacted with an excess of an alcoholic hydrogen chloride solution. Trituration with ether separates crystals of the dihydrochloride salt, MP 224° to 226°C, (from U.S. Patent 3,058,979). 

The reactions of mercuric iodide, mercuric bromide, and mercuric chloride with the excited species produced in the hexafluoroethane plasma were examined first, as the expected products were known to be stable and had been well characterized 13). Thus, these reactions constituted a "calibration of the system. Bis(trifluoromethyl)mercury was obtained from the reaction of all of the mercuric halides, but the highest yield (95%, based on the amount of metal halide consumed) was obtained with mercuric iodide. The mole ratios of bis(trifluoro-methyDmercury to (trifluoromethyl)mercuric halides formed by the respective halides is presented in Table I, along with the weight in grams of the trifluoromethyl mercurials recovered from a typical, five-hour run. 

With the exception of the reactions of trifluoromethyl radicals with sulfur vapor, which is really a separate class of reactions, if the power supplied to the load coil surrounding the reactor (see Fig. 2) was maintained at, or near, the minimum amount needed to support the discharge, in only two cases were compounds found that clearly resulted from reactions other than replacement of halogen by trifluoromethyl. The reaction of tellurium tetrabromide (or the chloride) gave, in addition to the products just reported, very small proportions of such species as BrCF2TeCF2Br and (C2F5)2Te, which were isolated in yields of... 

Silicon tetra-chloride, -bromide, or -iodide ( 5 mmol) was similarly treated with (CF3)2Hg (1-20 mmol) at temperatures that varied from 0 to 100°C. Although CaFg, SiF4, and e.g., Hgl were produced, and identified by mass spectrometry, in no case were trifluoromethyl-substituted silanes discerned under the conditions employed. 

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