2.2.2- Trifluoroethanesulfonyl chloride

Hydrolysis of 2,2,2-trifluoroethanesulfonyl chloride has been found to proceed via intermediate sulfene (CF3CH=S02) formed by iilcB reaction. At pH 1.8-5.0 the (ElcB) mechanism applies, whereby water and hydroxide ion act, respectively, as the carbanion-forming base at low and high pH extremes. The ( lcB)rev reaction applies in dilute acid and is accompanied by the expected H-D exchange of substrate protons when D2O is used as solvent. 

Reaction of surface hydroxyl groups with 2,2,2-trifluoroethanesulfonyl chloride (tresyl chloride) yields sulfonate esters which in a subsequent step can be reacted with amino- or mercapto-modihed biomolecules for covalent immobilization... 

A simple method for the activation of hydroxyl group carrying supports such as agarose, cellulose, diol-silica, glycophase-glass or hydroxyalkyl methacrylate copolymer with 2,2,2-trifluoroethanesulfonyl chloride (tresyl chloride) was introduced by Nilsson and Mosbach [108] ... 

Alkyl N-tresylarylsulfonimides can be obtained by the reaction of (2) with tresyl chloride (2,2,2-trifluoroethanesulfonyl chloride). ... 

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