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Trifluoroacetyl triflate

Synthesis of a benzofuran ring was successfully realized from 0-arylated oximes in the presence of acidic catalyst (Fisher method) For example, oximes 24 in the presence of a mixture of trifluoroacetyl triflate (TFAT) and 4-dimethylaminopyridine (DMAP) in CH2CI2 at room temperature afforded 2-arylbenzofurans (25) in yields up to 99% (equation 11). ... [Pg.237]

Note 8), 69 g (75%) of trifluoroacetyl triflate (TFAT), is of 99% purity (Note 9), as determined by fluorine magnetic resonance (Note 10). [Pg.218]

Trifluoroacetyl triflate is probably the most powerful trifluoro-acetylating agent known, as evidenced by its reactivity toward several types of nucleophiles under mild conditions. A sterically hindered base, 2,6-di-... [Pg.219]

Trifluoroacetyl triflate Acetic acid, trifluoro-, anhydride with trifluoromethanesulfonlc acid (9) (68602-57-3)... [Pg.220]

The authors have shown that treatment of difluoroperiodinane (45) (82UP11900) with potassium hydroxide or water gives iodinane oxide (46). Trifluoroacetyl triflate (46) reacts to give periodonium ion (47). Addition of a strong electrophile such as SbF5 or trifluoroacetyl triflate yields fluoroperiodonium ion (48). [Pg.571]

Trifluoroacetic anhydride is usually used without base " and derivatization of alcohols and polyols can be carried out without additional solvent. Pyridine bases should only be considered when phenols are trifluoroacetylated. Activation is possible w ith benzotri-azole/ l-methylpyrrolidin-2-one. pyridin-2-one, and pyridin-4-one, although the latter pyridinones are less effective than imidazole.Trifluoroacetyl acetate is less reactive than trifluoroacetic anhydride. Alternative reagents are trifluoroacetyl triflate " and the related trifluoroacetyl phosphate." ... [Pg.582]

Trifluoroacetic acid, 59, 111, 300, 309,483 Trifluoroacetic anhydride, 188,484 Trifluoroacetic anhydride-Pyridine, 484 Trifluoroacetyl triflate, 485 N-Trifluoroacetylwllsonitine, 202 Trifluoroethanol, 28... [Pg.302]

Trifluoroacetyl triflate, CF3COSO2CF3 (1). Mol. wt. 258.11, b.p. 62.5°. This stable anhydride is prepared by treatment of an equimolar mixture of trifluoroacetic acid and triflic acid with P2O5 at reflux. [Pg.549]

Dehydration of a 2 1 mixture of CF3CO2H and TfOH with P2O5 affords trifluoroacetyl triflate (eq 3), which is a very reactive agent for trifluoroacetylations at O, N, C, or halogen centers (eq 3). ... [Pg.498]


See other pages where Trifluoroacetyl triflate is mentioned: [Pg.419]    [Pg.526]    [Pg.531]    [Pg.217]    [Pg.228]    [Pg.419]    [Pg.526]    [Pg.531]    [Pg.1307]    [Pg.419]    [Pg.415]    [Pg.225]    [Pg.232]    [Pg.51]    [Pg.172]   


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