Trifluoroacetyl

The asymmetric reduction of oximes of 2-trifluoroacetyl furan, by using diborane with a chiral amino alcohol, has also allowed synthesis of both enantiomers of trifluoroalanines in an elegant manner. The key step in this synthesis is the separation of the (Z) and ( ) isomers of the oximes (Figure 5.4). ... 

Heptafluoro-2-trifluoroacetyl- F10b2, 264f. (F3C-CO-CO-C3F7/SbF5) Hep(afluoro-2-(rilluoroitietbyI-E10b2. 264 (FjC-CO 0, 1,/ SbF,)... 

Af-Trifluoroacetoxy-2,4-dinitroaniline, 2887 Trifluoroacetyl azide, 0623 2-Trifluoroacetyl-1,3,4-dioxazalone, 1044 0-Trifluoroacetyl-5-fluoroformyl thioperoxide, 1047 Trifluoroacetyl hypochlorite, 0591 Trifluoroacetyl hypofluorite, 0629 Trifluoroacetyhminoiodobenzene, 2898 Trifluoroacetyl nitrite, 0622 Trifluoroacetyl trifluoromethanesulfonate, 1054 Trifluoroacryloyl fluoride, 1046... 

I.I.7.I V-2-Benzoyl-l-methylvinyl, iV-2-Acetyl-l-methylvinyl, and iV-2-(Trifluoroacetyl)vinyl Groups... 

More recently, the 2-(trifluoroacetyl)vinyl group (4,4,4-trifluoro-3-oxobut-l-enyl, 126) was proposed for the N-protection of amino acids.This enamine derivative is readily prepared with 4-ethoxy-l,l,l-trifluorobut-3-en-2-one and NaOH at room temperature in 1-3 hours. Acidic workup leads to the protected amino acids in yields ranging from 70-89% without racemization. Cleavage is achieved with 3 M HCl in dioxane at room temperature in 10 hours. 

A transition metal-mediated approach to amidation of glycal substrates can lead to the formation of 2-deoxy-2-trifluoroacetyl-amido derivatives. Thus, when a solution of (saltmen)Mn(N) is added to a mixture of trifluoroacetic anhydride (TFAA) and glycal 107 followed by sequential treatment with thiophenol and BF3 Et20, the 2-A-trifluoroacetamido thioglycoside 108 can be obtained in good yield and excellent diastereoselectivity (O Scheme 53) [91]. 

A review on fluorinated 1,3-diketones, 2-trifluoroacetyl phenols and their... 

Preparation of 2 ,3 -dihydro-6 ,7 -methylenedioxy-2 -trifluoroacetyl-spiro[cyclo-hexa-2,5-dien-4-one-l,4 -(lH)isoquinoline]-3 -carhoxylic acid methylamide 194 [125] Polymer-supported diacetoxyiodobenzene 185 (5.82 g, 7.5 mmol, 1.1 mmol g 1.5 equiv.) was added portionwise over 10 min to a solution of... 

AI-Methyl-N-(2,2,2-trifluoroacetyl)amino]butyl, 952 4- (AI-Trifluoroacetylamino) butyl, 953... 

The phosphoramidite method was used to introduce this group. It was developed as a low-cost alternative to the 4-[A/-methyl-A/-(2,2,2-trifluoroacetyl)amino]butyl group. It is cleaved thermally at 90 C and at pH 7 in 3h. ... 

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