Trifluoro-A- trifluoromethyl sulfonyl-V trimethylsilyl methanesulfonamide

As Oxophilic Lewis Acid. In search for Lewis acids of mild acidity and devoid of nucleophilic anion, Yu and coworkers found that PhsPAuOTf offered the best results in the glycosidation of 1,2-anhydrosugars, increasing yields by 20% compared to the conventional protocol based on superstoichiometric anhydrous ZnCl2. Complex 1 was less efficient (eq 18). 

In Hashmi s study of hydroarylations with pyrroles,multiple substitutions were observed using 1 as well as AgPFe and TsOH. Likely, complex 1 was acting as a Lewis acid activating the methyl vinyl ketone (eq 19). 

14 -Trifluoro-iV- [(trifluoromethy 1) -sulfonyl]-A -(trimethylsilyl)methane-sulfonamide 

Solubility soluble in most common organic solvents, commonly used in dichloromethane, toluene, diethyl ether. 

Handling, Storage, and Precautions flammable, corrosive, very 

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