Triflamides oxidation

Furthermore, the use of the electrophilic fluorinating reagent 11 to effect oxidative formation of C—F bonds in 8-methylquinoline (9) was reported [22], More recently, a versatile palladium-catalyzed ortho-fluorination of the triflamide-protected benzyla-mine 12 was disclosed, which also made use of electrophilic fluorinating reagents (Scheme 9.4) [23]. 

Keto-esters.—Further examples of alkylations of the acyl anion equivalent (105) have been reported (c/. 2, 226 3, 16). Only in some cases can good yields of a-keto-ester dimethyl acetals be realized. In an extension of earlier work, N-aryl-triflamides have been found to be useful reagents for the overall oxidation of a-bromo-esters to a-keto-esters. Benzoylformates are accessible by carboxylation of anions derived from 2-aryl-l,3-dithians this approach seems to be an improvement on existing methods. 

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