Trientine hydrochloride

Treatment While damage cannot be cured, disease progression can be slowed down by lifelong chelation therapy. These chelating agents (including d-penicillamine or trientine hydrochloride) can help remove copper from tissue, and zinc supplements may help slow copper absorption, but patients also need to follow a diet low in copper. In extreme conditions where patients do not respond to treatment, liver transplantation may be an option. 

Trientine hydrochloride is a chelating agent, which forms chelate with copper, facihtating removal from the body. It is indicated in the treatment of Wilson s disease in patients intolerant of penicillamine. 

By January 1991, 50 orphan products had been approved for the treatment of 58 rare conditions. Companies had received 12 million in tax credits for orphan research. The classic orphan drug cases had been sorted out. For example, trientine hydrochloride, H2N(CH2)2-NH(CH2)2NH(CH2)2NH2.HC1, a chelating agent used to remove excess copper in Wilson s disease for patients who... 

S3rprine (Trientine hydrochloride). Merck Co., Inc. US Prescribing information, January 2001. 

Trientine Hydrochloride, USP Triethyl Citrate, NF Organic volatile impurities. Method I < 467 > Assay C 0.32... 

Chloro-4,5-dimethyl-1,3,2-dioxaphospholane, see C-00099 Trientine hydrochloride, in T-00232 2,2 -Dithiobis[l-naphthaleneamine], D-01118 2,2 -Dithiobis[l-... 

Dubois RS, Rodgerson DO, Hambidge KM. Treatment of Wilson s disease with triethylene tetramine hydrochloride (Trientine). J Pediatr Gastroenterol Nutr 1990 10(1) 77-81. 

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