Trienes formation

The reaction with furan forms a mixture of the two products with a preference for the [3+4] cycloadduct 88. Similarly, the reaction of furan with the vinylcarbenoid of si-loxy-substitilted vinyldiazoacetate 87 yields 90% of the [3+4] cycloaddition product with no triene formation. 

Proteinuria/ Interstitial nephritis T recruitment and activation of lymphocytes, likely through leuko-triene formation, affecting glomerular and peritubular permeability Fenoprofen use, possibly female gender, advanced age Discontinue NSAID, support with dialysis and steroids, if needed... 

Scheme 10-27 Triene formation and subsequent IMDA reaction proceeds with high efficiency and selectivity.

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