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Tricyclic antidepressants genetic polymorphism

Drugs that are metabolized by the cytochrome P-450 (CYP) isoenzymes CYP2D6, CYP2C9, and CYP2C19 also exhibit genetic polymorphisms. An example of CYP2D6 metabolism is debrisoquine. In about 5-10 /o of Caucasians in North America and Europe and about 1% of Asians, 4-hydroxylation of debrisoquine is reduced, and such individuals are at increased risk for toxicity (orthostatic hypotension). Beta blockers (metoprolol and timolol), antiarrhythmic drugs (encainide and flecainide), tricyclic antidepressants... [Pg.1018]

See other pages where Tricyclic antidepressants genetic polymorphism is mentioned: [Pg.196]    [Pg.64]    [Pg.122]    [Pg.602]    [Pg.608]    [Pg.692]    [Pg.1929]    [Pg.93]    [Pg.496]    [Pg.117]    [Pg.144]    [Pg.65]    [Pg.512]    [Pg.424]    [Pg.16]    [Pg.88]    [Pg.68]   
See also in sourсe #XX -- [ Pg.87 , Pg.88 ]



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Antidepressants genetic polymorphism

Antidepressants, tricyclic

Genetics polymorphism

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