1,1,2-trichloro 1,2,2-trifluoroethane toxicity

Several different solvents have been used. These include petroleum ether, diethyl ether, chloroform, and carbon tetrachloride. Of these, petroleum ether and diethyl ether are highly flammable, whereas chloroform (although a very good solvent) and carbon tetrachloride are toxic. Thus, these solvents are not recommended for use. Currently, 1,1,2 trichloro, trifluoroethane (Freon 113) is used when infrared (IR) absorbance is used for analysis. However, these solvents are being phased out because of potential interference with the ozone layer in the atmosphere. Studies are currently under way to find a replacement solvent. Potential candidates include hexane, cyclohexane, methylene chloride, perchloroethylene, and a commercial hydro chlorofluorocarbon (DuPont 123). When the gravimetric technique is used for analysis, 1,1,1-trichloroethane or dichloroethylene may also be used. 

Trichloro-1,2,2- trifluoroethane. 1,1,2-T richloro-1,2,2-trifluoroethane or fluorocarbon-113 (OES 1000 ppm 8h TWA) is possibly the least toxic of the solvents that have been in common use within this group. Apart from CNS effects and the ability to cause cardiac sensitisation at very high exposure levels, this solvent has been shown to cause few adverse effects. This absence of systemic toxicity is attributable to a rapid rate of elimination from the body and a very low degree of metabolism. This solvent is being phased out of production under the Montreal Protocol. 

Some common uses of haloalkanes include solvents and anesthetics. For many years, carbon tetrachloride was widely used in dry cleaners, and in home spot removers to take oils and grease out of clothes. However, its use was discontinued when carbon tetrachloride was found to be toxic to the liver, where it can cause cancer. Today, dry cleaners use other halogenated compounds such as dichloromethane, 1,1,1-trichloroethane, and l,l,2-trichloro-l,2,2-trifluoroethane. 

---