Tricarboxylic acid cycle thiamin deficiency

Magnesium is closely associated with calciiun and phosphorus. About 70 per cent of the total magnesium is found in the skeleton but the remainder, which is distributed in the soft tissues and fluids, is of crucial importance to the well-being of the animal. Magnesium is the commonest enzyme activator, for example in systems with thiamin pyrophosphate as a cofactor, and oxidative phosphorylation is reduced in magnesium deficiency. Magnesium is an essential activator of phosphate transferases (e.g. creatine kinase) and it activates pyruvate carboxylase, pyruvate oxidase and reactions of the tricarboxylic acid cycle therefore, it is essential for the... 

Altered activity of a-ketoglutarate dehydrogenase complex (ICGDHC), a key enzyme of the tricarboxylic acid cycle, is a major contributor to damage resulting from thiamine deficiency. 

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