Triazolopyridines ring-opening reactions

There are very few homolytic reactions on triazolopyridines. A suggestion that the ring opening reactions of compound 1 involved free radical intermediates is not substantiated (98T9785). The involvement of radical intermediates in additions to ylides is discussed in Section IV.I. The reaction of radicals with compound 5 and its 1-substituted derivatives gives 4-substituted compounds such as 234 (96ZOK1085). A more detailed study of the reaction of the 1-methyl and 1-phenyl derivatives with r-butanol and ammonium persulfate produced 4-methyl substitution with a silver nitrate catalyst, and the side chain alcohol 235 without the catalyst (96ZOK1412). 

General chemical properties of triazolopyridines, such as oxidations, reductions, reaction with electrophiles, reactions with nucleophiles, homolytic reactions, ring-opening reactions, and photochemical reactions can be found in <2002AHC(83)2>. 

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