Triazoles azide structural properties

A large number of peptidomimetics are currently entering clinical trials, typically protease inhibitors and anti-cancer agents, which emphasizes the importance of developing reactions which efficiently modify peptides or peptide-like structures to increase their drug-like properties. Azides are important dipoles in 1,3-dipolar cycloaddition reactions and react with dipolarophiles such as alkynes and nitriles, to afford [l,2,3]-triazoles and tetrazoles, respectively. 

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