1.2.3- Triazole microwave spectrum

The microwave spectrum of the parent 1,2,3-triazole was interpreted in terms of the l//-form <70SA(A)825>. The microwave spectrum of a highly enriched sample of V-deuterio-1,2,3-triazole was also assigned unambiguously, apparently to the 1-deuterio form <74CC605>. However, analysis of the microwave spectra of the parent molecule, the highly enriched species, and the V-deuterated... 

The observed dipole moment of (1) in dioxan is 10.57 x 10 C m and that obtained from the microwave spectrum of the vapour is 9.07 x 10 C m. Values have been tabulated <84CHEC-I(5)733 p. 743>. Theoretical calculations for the dipole moment of (1) gave values for the IH-tautomer that were closely in agreement with the observed value of triazole, whereas the calculated values for the 4H-tautomer were much higher. 

The microwave spectrum of triazole in the vapour phase also supports the IH structure (71CC873) for the monomer known to be the species present in the gaseous state (i892CB225). 

The combination of CuAAC and RuAAC offers the possibility of synthesizing triazoles with diverse residues and facilitates the alternation of the regioselectivity. As such, a broad spectrum of substrates is available and used, for example, in the derivatizion of nucleosides through the synthesis of triazole analogs. AgrofogUo et alJ° synthesized a small library of 1,4- and 1,5-disubstituted triazolo derivatives and compared the yielded ratio under Cu(I)- as well as Ru(II)-catalysis (with microwave irradiation) (Scheme 9.7). 

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