1.3.5- Triaza-7-phosphatricyclo decane

Allardyce CS, Dyson PJ, Ellis DJ, Heath SL (2001) [Ru(r 6-p-cymene)Cl2(pta)] (pta = l,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane) a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells. Chem Commun 1396-1397... 

More recent studies, also including in vivo evaluations, have been undertaken on ruthenium(ll)-arene complexes with the l,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane (PTA) co-ligand, viz. [Ru(77 -arene)Cl2(PTA)] 11 and ethy-lenediamine co-ligand, viz. [Ru(77 -arene)Cl(dien)] (dien = ethylenediamine) 12." ... 

DNA binding was observed for [H4Ru4(C6H6)4] and Ru3(CO)9(l,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane)3 in methanol-water and water. The clusters have good water solubilities, and their ability to bind DNA suggests that they may have applications as anticancer drugs. 

Catalytic and single-turnover experiments with the R. sphaeroides DMSO reductase, 0-labeled DMSO and l,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane as an oxygen atom acceptor have been used to demonstrate that the enzyme is an oxotransferase. Complementary resonance Raman studies have been interpreted on the basis of a direct mechanism for OAT, with the active site cycling between mono-oxo-Mo(VI) and des-oxo-Mo(IV) forms via a DMSO-bound Mo(IV) intermediate. Both MPT dithiolene groups stay firmly attached to the molybdenum throughout the catalytic cycle. However, EPR and UV/visible spectroscopic evidence has been interpreted on the basis of the species formed upon the addition of DMS to oxidized... 

RAPTA ruthenium arene PTA whereby PTA is the ligand l,3,4-triaza-7-phosphatricyclo- [3.3.1.1] decane SAHA suberoylanilide hydroxamic acid... 

Allardyce et al. [36] have noted that some phosphine complexes of the type [(ri -p-cymene)RuX2(pta)] (23, Fig. 2.9, where X = Cl, NCS, and pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane) exhibit antibacterial activity, but no doses were specified. They suggested that proteins rather than DNA may be the target sites. These complexes are inactive against Herpes and Polio viruses but the cluster complex [H4Ru4(ri -benzene)4] was active against Polio virus. 

PC6H12N3, 1,3.5-triaza-7-phosphatricyclo-[3.3.1.1]decane, 32 41 PC7H15IN3, 1-methyl-3,5-diaza-l-azonia-7-phosphatricyclo[3.3.1. IJdecane iodide, 32 43... 

Daigle DJ (1998) l,3,5-Triaza-7-phosphatricyclo[3.3.1.1 ]decane and derivatives. Inorg Synth 32 40-45... 

Krogstad DA, Ellis GS, Gunderson AK, Hammrich AJ, Rudolf JW, Halfen JA (2007) Two new water-soluble derivatives of l,3,5-triaza-7-phosphaadamantane (PTA) synthesis, characterization. X-ray analysis and solubility studies of 3,7-diformyl-l,3,7-triaza-5-phos phabicyclo[3.3.1 (nonane and l-pyridylmethyl-3,5-diaza-l-azonia-7-phosphatricyclo [3.3.1.1] decane bromide. Polyhedron 26 4093-4100... 

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