Triaole-Derived Anticancer Agents

Cancer, also called malignant neoplasm, is caused by the disorder of cell proliferation mechanism and has become a major health burden in developed and developing countries. Although several anticancer agents are in clinical use and have significant curative effects, it is still necessary to screen new molecules with different modes of actions. Enzymes, expressed at an estimated 18-29% within eukaryotic genomes [47], and enzyme inhibitors play a significant role in cancer therapy. 

A recent review [51] focuses mainly on the applications of click reaction in the synthesis of agents with mechanism-based anticancer activity, which are divided into four groups Topoisomerase 11 inhibitors, HDAC inhibitors, protein tyrosine kinase (PTK) inhibitors, and antimicrotubule agents. 

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