Triage filters

Some in silico studies have generated additional general rules comparable to Lipinski s rule of 5 or they have resulted in the development of triage filters from large commercially available databases (CMC, MDDR, WDI, etc.) or from internal company data useful for predicting solubility and absorption potential.A simple rule for rat bioavailability, for example, was... 

One answer to this dilemma is to use computational methods to identify the most interesting and informative compounds to pursue. Several workers have devised rules to identify undesirable or desirable compounds (3-12). These applications generally rely upon hard rules or structural criteria applied with limited focus to define interesting compounds. For example, the rule-of-five utilizes a score of 0-4 and is meant to assess bioavailability issues alone. Triage methods eliminate compounds that violate one or more of a variety of rules, which results in a limited set of compounds passing all filters. This is in some... 

Researchers from BMS have detailed the results of their efforts to enhance their HTS process [34]. Their papers discuss the subjectivity of the typical chemical structure triage process as it relates to HTS analysis, a topic worth some investigation by anyone involved in this type of selection process. With the aim of reducing subjectivity in this area, the authors systematically review their filters for physicochemical properties (this topic discussed in more detail below) and unwanted chemical moieties. Much of the work is aimed at understanding and detecting promiscuous compounds - those that initially appear to be hits in many screens (this topic discussed in more detail below). Importantly, the authors have made some of the related tools available for public use. 

Unusual clusters of illnesses Triage (first aid level) BLS procedures Portable gas-powered ventilation via mask and Guedel airway or bag-valve device with filter BLS levd management of haemorrhage contrd Patient conscious level s Salbutamol Situati( rqpoit ... 

Triage, re - evaluation and decontamination Endotracheal tube (intubation) Portable gas-powered ventilation (with filter) End-tidal CO2 Oximes ... 

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