Triacylglycerol-rich lipoproteins secretion

It has been suggested that Pgp plays a role in the transport of prcnyleystcin-rue thy 1 esters or cholesterol (58). In addition, esterification of cholesterol and triacylglycerol-rich lipoprotein secretion was inhibited by inhibitors of Pgp (59), whereas cholesterol seemed to be transported by Pgp also (60). 

Investigators have shown that a decrease in the release of tissue plasminogen activator (tPA) and an elevation of plasminogen activator inhibitor 1 (PAI-1) will reduce fibrinolytic function. It has emerged that triacylglycerol-rich lipoproteins stimulate PAI-1 secretion from endothelial cells, and furthermore it has been shown that OxLDL induces secretion, whereas native LDL has no detectable... 

The triacylglycerol (TG)-rich lipoproteins (very low density lipoproteins (VLDLs) and chylomicrons (CM)) are secreted into the circulation by hepatocytes of the liver and ente-rocytes of the intestine. All plasma lipoproteins share a common structure with a neutral lipid core, consisting of TGs and cholesteryl esters, surrounded by a surface monolayer of... 

Chylomicrons are the largest of the lipoproteins and the least dense because of their rich triacylglycerol content. They are synthesized from dietary lipids (the exogenous lipoprotein pathway) within the epithelial cells of the small intestine and then secreted into the lymphatic vessels draining the gut (see Fig. 32.13). They enter the bloodstream via the left subclavian vein. The major apoproteins of chylomicrons are apoB-48, apoCn, and apoE (see Table 34.3). The apoCn activates lipoprotein lipase... 

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