Triacetic acid-hydrolyzing enzyme

The enzyme hydrolyzing fumarylacetoacetic acid to fumaric and aceto-acetic acids has as yet been little studied. It may be the same as acylpyru-vase (592) or the triacetic acid hydrolyzing enzyme (154). 

Fumarylacetoacetate is split to fumarate and acetoacetate by an enzyme that was known previously to hydrolyze diketo acids. It has been called acylpyruvase, triacetic acid hydrolyzing enzyme, and /J-diketonase. Since both the rate of hydrolysis of fumarylacetoacetate and its affinity for the enzyme exceed those of other substrates there is some justification for the name fumarylacetoacetate hydrolase. The irreversible action of this enzyme results in the formation of products that are metabolized by the systems previously described for fatty acid oxidation and the Krebs cycle. 

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See also in sourсe #XX -- [ ]

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