Tri-ortho-tolylphosphine

In 2008, Vries group reported asymmetric hydrogenation of quinolines catalyzed by iridium complexes based on monodentate BINOL derived phos phoramidites PipPhos. They used tri ortho tolylphosphine and/or chloride salts as additives, and enantioselectivities were strongly enhanced to 89% ee (Scheme 10.13) [17]. Toluene and DCM were the best solvents, and the reaction was carried out at 60°C for 24h in the pressure of 50 bar H2, and a series of 2 substituted and 2,6 disubstituted quinolines were examined with excellent... 

The area of palladium-catalysed coupling reactions got a new impulse when in 1995 Herrmann and Beller published their work on the discovery of a palladacycle as a catalyst for the Heck reaction (Fig. 10.12) [102, 103]. It had been known earlier that tri-ortho-tolylphosphine is a very good ligand for the palladium-catalysed Heck... 

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