TREN-based template

Research by P. Scrimin and U. Toneiiato et ai. showed that Zn " was an aiiosteric reguiator of liposomal membrane permeability induced by synthetic template-assembled tripodal polypeptides. Several copies of peptide sequences from the peptaibol family were connected to fr/s(2-aminoethyl)amine (TREN), which is a tripodal metal ion ligand. The resulting tripodal polypeptides were capable of modifying the permeability of liposomal membranes, and their activity was tunable upon metal ion coordination of the TREN subunit. The synthesis of the TREN-based template began with the Stephen reduction of 4-cyanomethylbenzoate followed by the reductive amination of the resulting aldehyde with TREN. 

Custelcean and co-workers reported that tripodal tren-based tris(urea) host 38b complexed Ag2S04 to form a ID MOF structure with encapsulated sulfate ions. Interestingly, other silver salts did not result in MOFs. Therefore, the sulfate ion played a major role in the template process. Once again, the sulfate was bound by 12 H-bonds from six urea groups (Fig. 5.28) [79]. 

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