Template-assembled tripodal polypeptides

Research by P. Scrimin and U. Toneiiato et ai. showed that Zn " was an aiiosteric reguiator of liposomal membrane permeability induced by synthetic template-assembled tripodal polypeptides. Several copies of peptide sequences from the peptaibol family were connected to fr/s(2-aminoethyl)amine (TREN), which is a tripodal metal ion ligand. The resulting tripodal polypeptides were capable of modifying the permeability of liposomal membranes, and their activity was tunable upon metal ion coordination of the TREN subunit. The synthesis of the TREN-based template began with the Stephen reduction of 4-cyanomethylbenzoate followed by the reductive amination of the resulting aldehyde with TREN. 

Scrimin, P., Tecilla, P., Tonellato, U., Veronese, A., Crisma, M., Formaggio, F., Toniolo, C. Zinc(ll) as an allosteric regulator of liposomal membrane permeability induced by synthetic template-assembled tripodal polypeptides. Chem.-Eur. J. 2002, 8, 2753-2763. 

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See also in sourсe #XX -- [ ]

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