Trbger’s bases

Reduction of 3-methyl-4(3H)quinazolinone with lithium aluminum hydride is known to give 3-methyl-l,2,3,4-tetrahydroquinazoline. The most interesting tetrahydroquinazoline is Trbger s base ° since it has added to our knowledge of the stereochemistry of tri-... 

Most chiral trisubstituted amines can t be resolved into enantiomers because nitrogen pjTamidal inversion occurs too rapidly, but the substance known as Troger s base is an exception. Make a molecular model of Trbger s base, and then explain why it is resolvable into enantiomers. 

The validity of the transport-dispersive model was further successfully confirmed by experiments with other chromatographic systems such as Trbger s base (Mihlbachler et al., 2001 Jupke, 2004), the WMK-Keton (Epping, 2005), and fructose-glucose (Jupke, 2004). 

Synthesis and appHcations of Trbger s base analogues 12EJO7015. Synthesis and chemical transformations ofazonine derivatives 12X2081. Synthesis of 3,7,9- and 2,6,9-triazabicyclo[3.3.1]nonane derivatives 13H(87)2001. 

In general, it is now accepted that the mechanism for the formation of Trbger s bases involves a series oiin-situ Friedel-Crafts reactions of 125, butthe detailed course of the reaction has not yet been fully established. In trying to elucidate major mechanistic aspects, different methylene sources as well as different anilines have... 

Trbger s base R,S-2,2,2-Trifluoro-l-(9-anthryl)ethanol ( )-2-(4-chloro-6-methyl-amino-( 1,3,5)triazin-2-ylamino)-2-methyl-butyroniirile... 

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