Trazodone, synthesis

Due to the important pharmacological applications of this system, in particular the antidepressant trazodone, numerous articles deal with either its synthesis, or its incorporation into more complex substances, as a pharmacophore (see Section 11.13.12). Synthetic methods have been reviewed <1996CHEC-II(8)367>, and most of them are still in use or have been modified. Recent literature essentially focuses on the formation of the triazole ring. 

M., Fossa, P., Giannaccini, G., Manetti, F., Strappaghetti, G., Corsano, S. ar Adrenoceptor antagonists. Rational design, synthesis and biological evaluation of new trazodone-like compounds. 

The l,2,4-triazolo[4,3-fl]pyridine nuclens can be accessed by cyclocondensation of 2-hydrazino-pyridines the synthesis of the antidepressant trazodone, shown below, is an example. Condensation of 2-hydrazinopyridines with carboxylic acids, promoted by polymer-supported triphenylphosphine with tri-chloroacetonitiile and heated with microwave irradiation, is also efficient. °... 

Trazodone is a serotonin uptake inhibitor that has anti-depressant activity. It has been found to be more efficient in treating depressive disorders associated with insomnia and anxiety. The synthesis of trazodone involves construction of piperazine moiety and triazole moiety and is followed by a coupling reaction between two moieties. A microwave synthesis has also been an optimized method for synthesizing trazodone. ... 

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