Transplant biology

Transplant biology is important not only because of its direct clinical relevance, but also because it can serve as a model system for pathophysiologic... 

Polymers Controlled drug delivery Skin transplant Biological membranes ... 

Prof. Dr. Jeffrey L. Platt Transplantation Biology and the Departments of Pharmacology and Experimental Surgery, Immunology and Pediatrics Mayo Clinic Rochester, MI 55905 USA... 

Libby P (1996) Transplantation associated arteriosclerosis potential mechanisms. In TilneyN, Storm T, Paul L (eds) Transplantation biology cellular and molecular aspects. Lippincott-Raven, Philadelphia, pp 577-586... 

Biologicals. Figure 3 Fusion protein construction combination of the molecular component of interest with the constant region (Fc) of an antibody molecule, usually immunoglobulin (lg)G1 Fc, imparts the Fc function on to the molecularcomponentfortherapeutic use. The example given is ofCTLA4-lg, derivatives of which have shown clinical efficacy in the treatment of rheumatoid arthritis and transplant rejection. 

P-glycoprotein, a plasma membrane transport protein, is present in the gut, brain, liver, and kidneys 42 This protein provides a biologic barrier by eliminating toxic substances and xenobiotics that may accumulate in these organs. P-glycoprotein plays an important role in the absorption and distribution of many medications. Medications that are CYP3A4 substrates, inhibitors, or inducers are also often affected by P-glycoprotein therefore, the potential for even more DDIs exists in transplant recipients.42... 

Before examining the potential roles of chemokines in the pathophysiology of transplant rejection, it is important to review the biology that underlies the rejection of solid organ allografts. 

Belperio JA, Keane MP, Burdick MD, et al. CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury. J Immunol 2005 175 6931-6939. 

Cellular Carriers. Erythrocytes, leukocytes, platelets, islets, hepatocytes, and fibroblasts have all been suggested as potential carriers for drugs and biological substances. They can be used to provide slow release of entrapped drugs in the circulatory system, to deliver drugs to a specific site in the body, as cellular transplants to provide missing enzymes and hormones (in... 

Weissman C, Raeber AJ, Shmerling D, Aguzzi A, Manson JC. Knockouts, transgenics, and transplants in prion research. In Prusiner SB, ed. Prion Biology and Diseases. Vol. 38. Cold Spring Harbor, NY Cold Spring Harbor Press, 1999 273-305. 

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