Translocation of Glucokinase

The balance between the active and the inactive form is described as a simple chemical reaction with two rate constants (kact, ki), as seen in Fig. 6.2a. It is assumed that 

G6P can in some cells be dephosphorylated by glucose-6-phosphatase, GP. The metabolite S downstream of the glycolysis is considered to be responsible for the removal of glucose. The balance between 

With the active fraction Xa = GKa/GKt, the time course of the translocation is described by the equation  

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Fig. 6.3 Steady state relation between the metabolite S normalized by the value, Si, = vmaxGKf/b and the glucose concentration, G, for different values of the maximal active fraction Xmax. The smallest active fraction value, Xq, is set equal to 0.1. The main effect of the translocation of glucokinase is a right hand shift of the relation, resulting in a threshold value forthe glucose sensor.

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