Translational and rotational dynamics of water molecules in the grooves

As in the ease of protein hydration, water moleeules again play a dual role. First and foremost, they provide stability to the observed nueleie aeid conformation. Second, they stabilize, often for a long duration, complexes with diverse proteins and intercalators. In the latter cases, localized ordered water molecules facilitate formation of specific nucleic acid stmctures around external molecules/groups [3]. The detailed structural morphology of the DNA hydration stmcture is illustrated in Appendix 10. A. 

As already emphasized, study of the hydration dynamics of DNA is complex. We need to understand both the group-specific and the base pair sequence-specific dynamics of water. 

The rotational motion of a small but strongly interacting molecule such as water is a good measure of the mobility (or fluidity) of a small region because the relaxation occurs in a relatively small time window (compared to translational diffusion, which 

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Translational and rotational dynamics of water molecules in the grooves 153... 

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