Transient Fisher information

Figure 8.6 Transient Fisher information for the two scenarios base case with blue (gray in print versions) color representing the top graph consumption increase scenario red (light gray in print versions) color representing the bottom graph.

Fisher 1998 demonstrates that the more that is learned about the biomarker (half-life, time course in blood or urine, and development of PBPK model) and the exposed population (age, body weight, pharmacoge-netic traits, behavioral factors that affect exposure, and time between exposure and sample measurement), the more refined dose estimates can become. Without such information, a highly transient metabolite like TCE is not a reliable marker of exposure, unless exposure is nearly continuous and uniform. That may not be the case in the general population, so TCE in blood may not be a good biomarker for assessment of general-population exposure, although PBPK models are available to extrapolate from biomarker concentration to external dose in both animals and humans (Clewell et al. 2000). 

---

See also in sourсe #XX -- [ , ]

---