Transglycosylation for the Synthesis of Nucleosides

In this section some examples are discussed in order to prepare nucleoside analogs by base interchange through a transglycosylation reaction. In these processes two different types of intramolecular enzymes are usually employed nucleoside phos-phorylases and N-2 -deoxyribosyl transferases. 

20 depicts the versatUily of this reaction using whole cells as biocatalysts. In 

1 Gotor-FemSndez, V. and Gotor, V. (2007) Use of lipases in organic synthesis, in Industrial Enzymes Structure, Function and Application (eds ). Polaina and A.P. MacCabe), Springer, Dordrech, The Netherland, Chapter 18. 

5 Ferrero, M. and Gotor, V. (2000) Biocatalytic synthesis of steroids, in Stereoselective Biocatalysis (ed. R.N. Patel), Marcel Dekker, New York, USA, Chapter 

Cretton-Scott, E., Schinazi, R.F., Myers, M Bryant, M.L. and Sommadossi, J.-P. (2001) Antiviral Chemistry Si Chemotherapy, 12,119-129. 

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