Transgenic mouse models isoforms

Jay et al., 2011). The tau transgenic mouse models overexpress the human tau isoform and also exhibit AD-like symptoms (Shah et al., 2010). In these models, human tau protein is expressed and hyperphosphorylated, but the mice do not develop Ap deposits. 

In the recent years, an increasing number of studies show widespread relevance of the CaMK cascade. From the recent description of new isoforms, such as those of the CaMKI subfamily, to the analysis of mouse models null or transgenic... 

These findings may indicate that perhaps ApoE is involved in the clearance or routing out of A]8 from the CNS and that the presence of e4 impairs the process, thus leading to its accumulation. Either alone or in complex with A/3, ApoE seems to have no effect on APP processing (52). A critical and isoform-specific role of ApoE in SP formation has been demonstrated in a mouse model (54). In that model of FAD, transgenic mice expressing... 

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