Transferrin transport vector

Alternatively, monoclonal antibodies (Mabs) to the relevant receptors can be used as transport vectors. Anti-insulin (Mab83-7 and Mab83-14) and anti-transferrin (0X26) receptor antibodies have been proposed as efficient and selective BBB transport vectors. The antitransferrin receptor antibody binds to a site removed from the transferrin binding site and therefore does not compete with endogenous transferrin for transport across the BBB. Studies using radiolabeled peptides have shown that significant uptake of a... 

There is considerable interest in developing pharmaceuticals that use specific carriers to gain entry to the brain. For example, enhanced transport has been observed for agents coupled with antibodies that bind the transferrin receptor as well as other vectors [59, 60], Increased uptake of proteins into the brain has been reported after cationization [61], which appears to enhance endocytosis, perhaps due to improved interactions between the cationic protein and the negatively charged cell surface. ... 

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