Transfer hydrogenation of quinolines

Isolated yield. The values in parentheses are GC yield. Reaction for 24 h. 

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Asymmetric Synthesis Based on Hydrogen Transfer 113 Table 5.2 Transfer hydrogenation of quinolines catalyzed by [Cp lrCl2]2 (1) ... 

Highly Enantioselective Brpnsted Acid Catalyzed Transfer Hydrogenation of Quinolines Development... 

Transfer Hydrogenation of Quinolines Development of a New Organocatalytic Cascade Reaction... 

Scheme 2. First Br0nsted acid catalyzed transfer hydrogenation of quinolines...

Cascade Transfer Hydrogenation of Quinoline and Pyridine Derivatives... 

Scheme 3.47 Transfer hydrogenation of quinolines using newly developed...

Transfer hydrogenation of quinolines has also been studied using a 3,3-linked dimeric BINOL derivative 2 in which both subunits are phosphorylated. ... 

Rueping M, Antonchick AR, Theissmann T (2006) A Highly Enantioselective Br0nsted Acid Catalyzed Cascade Reaction Organocatalytic Transfer Hydrogenation of Quinolines and Their Application in the Synthesis of Alkaloids. Angew Chem Int Ed 45 3683... 

Fig. 33 Asymmetric transfer hydrogenation of quinolines using a tethered catalyst...

For example. Rueping and coworkers reported a highly enantioselective transfer hydrogenation of quinolines by means of 1 (Scheme 11.14) [26]. This method offered a wide variety of chiral quinoUnes with good to excellent enantioselectivities (88-98% ee) and low catalyst loading (2mol%). Its elegant appUcation to various isoquinoline alkaloids was also demonstrated. 

Scheme 11.14 Asymmetric transfer hydrogenation of quinoline derivatives.

Rueping M, Antonchick AP, Theissmann T. A highly enantioselective Brpnsted acid catalyzed cascade reaction organocatalytic transfer hydrogenation of quinolines and their application in the synthesis of alkaloids. Angew. Chem. Int. Ed. 2006 45 3683-3686. 

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