Trans-cyclohexane dimethanol

FIGURE 2 Glass transition temperature of a polymer prepared from 3,9- bis ( ethylidene- 2,4,8,10-tetraoxaspiro [ 5,5 ] undecane ) and mixtures of trans-cyclohexane dimethanol and 1,6-hexanediol as a function of mol% 1,6-hexanediol. (From Ref. 13.)... 

FIGURE 8 Cumulative release of methylene blue (o), [1,4 - 14c] succinic acid (a), and polymer weight loss ( ) from polymer discs prepared from 3,9-bis(ethylidene-2,4,8,10-tetraoxaspiro[5,5Jundecane) and a 50 50 mole ratio of trans - cyclohexane dimethanol and 1,6-hexanediol at pH 7.4 and 37°C. Polymer contains 0.1 wt% [1,4 — [succinic anhydride and 0.3 wt% methylene blue. (From Ref. 

FIGURE 13 Cumulative release of -nitroacetanilide (PNAC) from polyester discs prepai ed from 3,9-bis(ethylidene-2,4,8,10-tetraoxas-piro[5,5]undecane) and a 60 10 30 mole ratio of trans-cyclohexane dimethanol, 1,6-hexanediol, and triethylene glycol at pH 7.4 and 37 C. PNAC content 2 wt% (o) 0 mol%, ( ) 0.25 mol%, ( ) 0.50 mol% 9,10-dihydroxystearic acid. (From Ref. 23.)... 

FIGURE 25 HPLC chromatograms of polymer samples hydrolyzed to cleave all ortho ester bonds. Samples were prepared at either 130, 145, or leO C. Polymer prepared from 3,9-bis(ethylidene-2,4,8,10-tetraoxaspiro)5,5]undecane) and a 25 75 mole ratio of trans-cyclohexane dimethanol and 1,6-hexanediol and contained 3 wt% phthalic anhydride and 7.5 wt% cyclobenzaprine hydrochloride (CBP). 

Fig. 11. Effect of drug loading on cumulative drug release from a polymer disk prepared from 3,9-bis (ethylidene-2,4,8,10-tetraoxaspiro [5,5] undecane) and a 50/50 mol ratio of trans-cyclohexane dimethanol and 1,6-hexanediol at pH 7.4 and 37 °C. Drug loading ( ) 8 wt%, (O) 6 wt%, ( ) 4 wt% and ( ) 2 wt% [32]. Reprinted with permission...

Cyclohexanedimethanol monoacetate. A mixture of cis tmd trans 1,4-cyclohexane dimethanol, (930 g, 6.448 moles) wtis dissolved in 3 L of tetrahydrofuran and 550 mL of pyridine, (7.69 moles) added. The solution was cooled in an ice bath and stirred under argon. An acetyl chloride solution, (506.4 g, 6.45 moles) in 500 mL of tetrahydrofuran was added dropwase over a 2 hour period. The ice bath was removed and the reaction mixture stirred for 2 hours at room temperature. It was then filtered to remove the pyridine HCl salt and evaporated to remove the tetrahydrofuran. The residue was dissolved in 2 L of ethyl acetate and the solution extracted with diluted aqueous HCl (2 x 300 mL), warm water (2 x 300 mL) and aqueous NaHC03 solution (2 X 300 mL). The ethyl acetate solution was dried over anhydrous MgS04 and the ethyl acetate removed on a rotoevaporator. Vacuum distillation of the residue yielded 335 g of product. GC analysis showed that the product contained 59% cyclohexanedimethanol monoacetate and 41% cyclohexanedimethanol diacetate. The overall yield of the monoacetate was 16.5%. 

Poly(oxysuccinoyloxymethylene-1,4-cyclohexylenemethylene) trans Poly(trans-1,4-cyclohexane dimethanol succinate)... 

Poly(oxyadipoyloxymethylene- 1,4-cyclohexylenemethylene) tram Poly(trans-J,4-cyclohexane dimethanol adipate)... 

Cyclohexanedimethanol CAS 105-08-8 EINECS/ELINCS 203-268-9 Synonyms Bis (hydroxymethyl)-1,4 cyclohexane 1,4-Bis (hydroxymethyl) cyclohexane 1,4-Bis (hydroxymethyl) cyclohexane (cis and trans) CHDM Cyclohexane-1,4-dimethanol... 

Figure 3.12 Gas chromatograms of hydrolysates of (a) silyl derivative of polyethylene terephthalate, (b) silyl derivative of ethylene glycol 1,4 butane diol and trans isomers of 1,4 cyclohexane diol dimethanol and (c) silyl derivative of iso- phthalic and terephthalic acids derived from a polyester. Reproduced with permission from B.J. Allen, G.M. Elser, K.P. Keller and H.D. Kinder, Analytical Chemistry, 1977, 49, 741. 1977, ACS...

---