Tramadol withdrawal syndrome

Drug withdrawal A withdrawal syndrome has been described in a neonate born to a mother who was taking tramadol 400 mg/ day for chronic low back pain [179 ]. During the last weeks of pregnancy, the dose was reduced to 200 mg/day. At 35 hours of age, the neonate had signs of severe withdrawal. The symptoms occurred earlier... 

Serotonin syndrome occurred in an 88-year-old woman who took sertraline 50-100 mg/day and tramadol 200-400 mg/day for 10 days the symptoms subsided 15 days after withdrawal of tramadol (124). 

A 29-year-old woman took tramadol 50 mg 6-hourly for pain associated with the carpal tunnel syndrome. She slowly increased the dose of tramadol and obtained it from several physicians and different hospitals, so that after 3 years she was taking 30 tramadol 50 mg tablets daily. She had two generalized seizures and stopped taking tramadol 1 day later she developed severe opioid withdrawal symptoms, including diarrhea, headache, insomnia, and blurred vision. She was detoxified with tapering doses of tramadol and discharged after 6 days. 

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