Traceless synthesis using polymer-bound triphenylphosphine

Traceless Synthesis Using Polymer-Bound Triphenylphosphine 

The Wittig reaction on solid supports offers the advantage that the phosphine oxide formed as by-product remains bound to the solid support and can thus be separated from the olefinic product by filtration. 

A phosphonium salt has been prepared from commercially available polymer- 

Treatment of key intermediate 119 with methoxide led to a toluene-type compound 120. An intramolecular Wittig reaction could also be achieved to yield a 2-substituted indole 121. The addition of an aldehyde resulted in a stilbene, e.g., 122 [142]. 

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Traceless Synthesis Using Polymer-Bound Triphenylphosphine... 

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See also in sourсe #XX -- [ ]

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