Trace amine associated receptors TAARs

Trace Amines. Table 1 The trace amine-associated receptor (TAAR) family... 

Hashiguchi Y, Nishida M (2007) Evolution of trace amine associated receptor (TAAR) gene family in vertebrates lineage-specific expansions and degradations of a second class of vertebrate chemosensory receptors expressed in the olfactory epithelium. Mol Biol Evol 24 2099-2107 Hashiguchi Y, Furuta Y, Kawahara R, Nishida M (2007) Diversification and adaptive evolution of putative sweet taste receptors in threespine stickleback. Gene 396 170-179 Hemess MS, Gilbertson TA (1999) Cellular mechanisms of taste transduction. Annu Rev Physiol 61 873-900... 

Trace amine-associated receptors (TAARs) are related to G protein-coupled aminergic neurotransmitter receptors such as dopamine and serotonine receptors and recognize derivatives of the classical monoamines such as B-phenylethylamine, octopamine, tryptamine, and tyramine. Initially, TAARs had been considered neurotransmitter receptors (Borowsky et al. 2001), but recently an expression in olfactory sensory neurons was shown for several mammalian taar genes, with expression characteristics very similar to odorant receptors (Liberies and Buck 2006). Thus the taar genes were recognized as a fourth GPCR family of olfactory receptors (Buck 2000). 

Hashiguchi Y, Nishida M (2007) Evolution of trace amine associated receptor (TAAR) gene family in vertebrates lineage-specific expansions and degradations of a second class of vertebrate chemosensory receptors expressed in the olfactory epithelium. Mol Biol Evol 24 2099-2107... 

Amphetamines are potent agonists at trace amine-associated receptors (TAARs), and their effects may be mediated in part via TAARs and in part via dopamine transport [iR E] pijgj.g jg emerging evidence [3 ] that TAAR are activated by trace amines such as p-tyramine, P-phenylethylamine, tryptamine, and octopamine in mammalian brain and blood vessels [4 ] a subtype receptor, TAARi, is a modulator of the dopamine... 

OR odorant receptor, TAAR trace amine-associated receptor, ND not determined From Niimura and Nei (2003) bFrom Grus et al. (2007)... 

---