Toxicology reaction mechanistic

D. W. (2005) Skin sensitization reaction mechanistic applicability domains for structure-activity relationships. Chemical Research in Toxicology, 18, 1420—1426. 

A mechanism of action describes the molecular sequence of events (covalent or non-covalent) that lead to the manifestation of a response. The complete elucidation of the reactions and interactions among and between chemicals, include very complex and varied situations including biological systems (macromolecular receptors, physical phenomena (thermodynamics of explosions) or global systems (ozone depletion). Unfortunately, this level of mechanistic detail is often unavailable but recent advances in molecular toxicology and others hazards, at the molecular level, have provided valuable information that elucidates key steps in a mechanism or mode of action. ... 

Such a more mechanistic approach of the reactional context is called reflexive toxicology [2] because it requires second thought and reasoning. It is not only indispensable any more to learn by heart lists of effects without understanding why or how they work. It is a very effective solution, which enables an important economy of means and time. 

Linking Chemical Reaction Mechanisms with Mechanistic Toxicology... 

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