Toxicokinetics genetic variability

TABLE 8.16 Studies of ALAD Genetic Variability in Pb Toxicokinetics ... 

In conclusion, the data and analyses performed by Renwick and Lazarus indicate that the 10-fold factor for human variability is an appropriate default value, but it has also identified a number of circumstances where this default value may be inadequate. For example, the 3.16 toxicokinetic factor could not cover human variability in the case of genetic polymorphisms. 

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