Toxicogenomics application

Neumann, N. F. Galvez, F. (2002). DNA microarrays and toxicogenomics applications for ecotoxicology Biotechnology Advances, 20, 391-419. 

Toxicology to Toxicogenomics Applications of Genomics in Toxicological Science... 

Rosenblum, L.Y., Toxicogenomic applications to drug risk assessment, Environ. Health Perspect., Ill, A804, 2003. 

The workshop participants concluded that it is premature for the FDA to write a guidance for industry because the science of genomics and its applicability to preclinical toxicogenomics assessment is rapidly evolving. If a guidance were to be developed in the future, questions and concerns would be raised about the following ... 

Based on the outcome of two OECD workshops (in 2003-2004), strategies concerning the future application of toxicogenomics in regulatory assessment of chemical safety are being developed by some OECD member countries (OECD 2007a). 

OECD. 2007a. OECD website. OECD activities to explore and evaluate regulatory application of genomic methods toxicogenomics. http //www.oecd.org/document/29/0,3343,en 2649 34365 34704669 l l l l,00.html... 

Pennie, W.D. and Kimber, 1. (2002) Toxicogenomics transcript profiling and potential application to chemical allergy. Toxicology In Vitro An International Journal Published in Association with BIBRA, 16, 319-326. 

Toxicogenomic Study Designs Applicable for Developmental Toxicology... 

Khor TO, Ibrahim S, Kong AN. Toxicogenomics in drug discovery and drug development potential applications and future ehallenges. Pliarm Res 2006 23 1659-1664. 

Metabonomics has received considerable attention in the toxicological community, but based on published literature, metabonomic applications do not appear to be as widely used as transcriptomics (toxicogenomics). However, this is not a reflection on the utility of the approach, but more likely a consequence of the need to have a complex infrastructure, particularly with respect to data analysis and interpretation in order to carry out the technology. 

Chin KV, Kong AN. Application of DNA microarrays in pharmacogenomics and toxicogenomics. Pharm Res 2002 19 1773-1778. 

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