Toxicity Risks and Physical Properties

In addition to underpinning chemical reactivity, physical properties play a role in several aspects of toxicity, for example binding to unwanted targets. 

Lipophilicity is a key drug-like attribute and is important for desolvation and binding to drug protein targets. It is not surprising therefore, that high lipophilicity may be responsible for off-target receptor promiscuity and subsequent 

There is direct evidence linking lipophilicity to the in vivo 

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