Toxicity procainamide-induced lupus

N-acetyltransferase (NAT2) Isoniazid, hydralazine, sulfonamides, amonafide, procainamide, dapsone, caffeine Hypersensitivity to sulfonamides, amonafide toxicity, hydralazine-induced lupus, isoniazid neurotoxicity... 

The dog is a species that is frequently used in toxicity studies. However, there are few reports in the open literature on dog studies with respect to chemical- or drug-induced hypersensitivity reactions or autoimmune effects, and those that are available lack consistency. For instance, procainamide has been shown to induce lupus-like symptoms (mainly an increase of ANA) in one study [63], but not in another study with younger dogs [64], Similar discrepancies have been observed for hydralazine-induced effects in dogs [5],... 

Another chemical class of drugs associated with inducing a lupus is the hydrazines. As with aromatic amines, there are few examples because most hydrazines are toxic. Hydralazine is second only to procainamide with respect to the incidence of lupus associated with its use [14], Although its present use is infrequent, the finding that it is... 

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