Toxicity endpoints also genotoxicity

The subcommittee also reviewed toxicologic and epidemiologic data on other endpoints hepato toxicity, renal toxicity, reproductive and developmental toxicity, cardiovascular toxicity, and genotoxicity of JP-8. No relevant adverse effects were observed for hepatotoxicity, renal toxicity, and cardiovas-... 

Other critical endpoints of lead toxicity include toxicity to the nervous system and the kidneys. Based on experimental findings, it seems plausible that lead has no direct genotoxic effects, which argues for establishing a practical threshold limit value for lead toxicity. Thus, an occupational exposure limit (OEL) based on avoiding functional CNS alterations is expected also to protect versus toxicity to the peripheral nervous system and the kidney, including possibly the development of renal cancer. 

---