Total Synthesis of the Natural Cembranoids

The wide-ranging biological activities exhibited by members of the cembranoid family of marine diterpenes, for example, deoxysarcophine, lophotoxin, sinularin, aseperdiol, and sarcophytol A, in combination with their diversity of structure and the lack of flexible synthetic methodology for the elaboration of 14-ring carbo-cycles, have made this family of natural products a particularly challenging area for the synthetic chemist. Methods that have been developed for macrocyclization in the cembranoid field include 

The synthetic strategy of cembrane-type diterpenes include (1) efficient methods for the construction of a 14-membered carbocyclic ring, (2) functional group assembly, and (3) stereochemistry control as the key reactions. Because the 

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