Total Synthesis of Mycinolide

The Hoffmann mycinolide synthesis is based on the coupling of the Ci-Cio (227) and Cn-Cu (232) segments. The configuration of the former segment 227 

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Ditrich, K., Bube, T., Sttirmer, R., and Hoffmann, R.W., Total synthesis of mycinolide V, the aglycone of a macrolide antibiotic of the mycinamycin series, Angew. Chem., Int. Ed. Engl., 25, 1028, 1986. Hoffmann, R.W., and Ditrich, K., Total synthesis of mycinolide V, Liebigs Ann. Chem., 23, 1990. Ditrich, K., Total synthesis of methynolide. Liebigs Ann. Chem., 789, 1990. 

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